If the bones aren't edited in any way it should be fine, hitboxes are attached to bones and I'm pretty sure hurtboxes are too, so missing objects shouldn't affect gameplay. Size modded things and the like will affect gameplay of course.
Really if you put it on your SD and it doesn't freeze it should be fine.
And the question here is how do I know if bones have been added or not? Should it say somewhere on the description?